Title of article
Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate
Author/Authors
Honglu Zhang، نويسنده , , Yong Xu، نويسنده , , Nicolas Markadieu، نويسنده , , Renaud Beauwens، نويسنده , , Christophe Erneux، نويسنده , , Glenn D. Prestwich، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
762
To page
766
Abstract
Metabolically-stabilized analogs of PtdIns(3,4,5)P3 have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analog of PtdIns(3,4,5)P3. Intracellular delivery of dipalmitoyl PtdIns(3,4,5)PT3-mimicked insulin in activating sodium transport in A6 cells.
Keywords
PtdIns(3 , 5)P3 , asymmetric synthesis , Activating sodium transport , Metabolically-stabilized , 4
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799055
Link To Document