Title of article
Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway
Author/Authors
Frédéric Stauffer، نويسنده , , Sauveur-Michel Maira، نويسنده , , Pascal Furet، نويسنده , , Carlos Garcia-Echeverria، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1027
To page
1030
Abstract
Imidazo[4,5-c]quinoline derivatives have been discovered and developed as potent and effective modulators of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) pathway to lead to clinical development candidates. The SAR data of representative examples of this compound class and their biological profiling in cellular and in vivo settings are presented and discussed.
Keywords
PDK1 , PI3K , Oncology , PI3K/PKB-pathway
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799106
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