Title of article
Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors
Author/Authors
Zhicai Wu، نويسنده , , John C. Hartnett، نويسنده , , Lou Anne Neilson، نويسنده , , Ronald G. Robinson، نويسنده , , Sheng Fu، نويسنده , , Stanley F. Barnett، نويسنده , , Deborah Defeo-Jones، نويسنده , , Raymond E. Jones، نويسنده , , Astrid M. Kral، نويسنده , , Hans E. Huber، نويسنده , , George D. Hartman، نويسنده , , Mark T. Bilodeau، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
1274
To page
1279
Abstract
This communication reports a new synthetic route of pyridopyrimidines to facilitate their structural optimization in a library fashion and describes the development of pyridopyrimidines that have excellent enzymatic and cell potency against Akt1 and Akt2. This series also shows a high level of selectivity over other closely related kinases and significantly improved caspase-3 activity with the more optimized compounds.
Keywords
Pyridopyrimidine , cancer , Akt , kinase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799150
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