Title of article
Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents
Author/Authors
Chunhui Zhou، نويسنده , , Jaeki Min، نويسنده , , Zhigang Liu، نويسنده , , Anne Young، نويسنده , , Heather Deshazer، نويسنده , , Min-Tian Gao، نويسنده , , Young Tae Chang، نويسنده , , Neville R. Kallenbach and Min Lu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1308
To page
1311
Abstract
Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.
Keywords
1 , 3 , 5-triazine , Membranolytic , Cationic antimicrobial peptide mimetic
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799157
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