Title of article
Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes
Author/Authors
Himanshu Atheaya، نويسنده , , Shabana I. Khan، نويسنده , , Ritu Mamgain، نويسنده , , Diwan S. Rawat، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1446
To page
1449
Abstract
Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H2O2/TFE in presence of MeReO3 as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of these tetraoxanes exhibited in vitro antimalarial activity without showing any cytotoxicity. Thermal stability of these compounds was studied by differential scanning calorimetry.
Keywords
Tetraoxane , antimalarial activity , cytotoxicity , differential scanning calorimetry
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799184
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