Title of article
Novel echinocandin antifungals. Part 1: Novel side-chain analogs of the natural product FR901379
Author/Authors
Masaki Tomishima، نويسنده , , Hidenori Ohki، نويسنده , , Akira Yamada، نويسنده , , Katsuyuki Maki، نويسنده , , Fumiaki Ikeda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1474
To page
1477
Abstract
A series of novel acylated analogs of the novel water-soluble echinocandin FR901379 have been prepared and evaluated for antifungal and hemolytic activity. A relationship between antifungal activity and lipophilicity of the acyl side chain, expressed as Clog P was demonstrated, and an analog (3c) with 5.5- to 8-fold superior in vivo activity relative to the previously disclosed 4-(n-octyloxy)benzoyl side chain analog, FR131535 obtained.
Keywords
Echinocandin , Candida albicans , Aspergillus fumigatus , Antifungal , natural product , FR901379 , FR13153
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799189
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