• Title of article

    4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors

  • Author/Authors

    Sylvie Frechette، نويسنده , , Silvana Leit، نويسنده , , Soon Hyung Woo، نويسنده , , Guillaume Lapointe، نويسنده , , Guillaume Jeannotte، نويسنده , , Oscar Moradei، نويسنده , , Isabelle Paquin، نويسنده , , Giliane Bouchain، نويسنده , , Stéphane Raeppel، نويسنده , , Frédéric Gaudette، نويسنده , , Nancy Zhou، نويسنده , , Arkadii Vaisburg، نويسنده , , Marielle Fournel، نويسنده , , Pu Theresa Yan، نويسنده , , Marie-Claude Trachy-Bourget، نويسنده , , Ann Kalita، نويسنده , , Marie-France Robert، نويسنده , , Aihua Lü، نويسنده , , Jubrail Rahil، نويسنده , , A. Robert MacLeod، نويسنده , , et al.، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    5
  • From page
    1502
  • To page
    1506
  • Abstract
    The synthesis and biological evaluation of a variety of 4-(heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs is described. Some of these compounds were shown to inhibit HDAC1 with IC50 values below the micromolar range, induce hyperacetylation of histones, upregulate expression of the tumor suppressor p21WAF1/Cip1, and inhibit proliferation of human cancer cells. In addition, certain compounds of this class were active in several human tumor xenograft models in vivo.
  • Keywords
    benzamides , anticancer agents , MGCD0103 , HDAC , Histone deacetylase inhibitors
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2008
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    799195

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799195