Title of article
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1′ modifications for the exploration of the S1′ subsite
Author/Authors
David N. Deaton، نويسنده , , Kevin P. Graham، نويسنده , , Jeffrey W. Gross، نويسنده , , Aaron B. Miller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
1681
To page
1687
Abstract
Explorations of the S1′ subsite of ACE2 via modifications of the P1′ methylene biphenyl moiety of thiol-based metalloprotease inhibitors led to improvements in ACE2 selectivity versus ACE and NEP, while maintaining potent ACE2 inhibition.
Keywords
metalloproteases , protease inhibitors , thiols , Angiotensin-converting enzyme 2
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799230
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