Title of article
Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3
Author/Authors
Julia Cianci، نويسنده , , Jonathan B. Baell، نويسنده , , Bernard L. Flynn، نويسنده , , Robert W. Gable، نويسنده , , Jorgen A. Mould، نويسنده , , Dharam Paul، نويسنده , , Andrew J. Harvey، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
2055
To page
2061
Abstract
Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones.
Keywords
Electrophysiology , Kv1.3 , chalcones , Natural product derivatives , Ion channel blockers , Conformational analysis , Molecular modelling , X-ray crystallography
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799298
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