Title of article
Synthesis and biological properties of β-turned Aβ31–35 constrained analogues
Author/Authors
M. Jes?s Pérez de Vega، نويسنده , , José Luis Baeza، نويسنده , , M. Teresa Garc?a-L?pez، نويسنده , , Miquel Vila-Perell?، نويسنده , , Carmen Jiménez-Castells، نويسنده , , Ana-maria Simon، نويسنده , , Diana Frechilla، نويسنده , , Joaquin del R?o، نويسنده , , Ricardo Gutiérrez Gallego، نويسنده , , David Andreu، نويسنده , , Rosario Gonz?lez-Mu?iz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2078
To page
2082
Abstract
A series of constrained pentapeptide analogues of the fragment Aβ31–35 has been prepared using solid phase synthesis protocols. The results of conformational studies and surface plasmon resonance (SPR) experiments seem to indicate that the affinity of these constrained analogues for immobilized Aβ25–35 peptide could be related to their ability to adopt a Leu34N-Ile31O β-turn-like folded conformation.
Keywords
Turn inducers , Peptide derivatives , surface plasmon resonance , ?-Amyloid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799302
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