Title of article
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)
Author/Authors
Amy Timmons، نويسنده , , Mark Seierstad، نويسنده , , Rich Apodaca، نويسنده , , Matt Epperson، نويسنده , , Dan Pippel، نويسنده , , Sean Brown، نويسنده , , Leon Chang، نويسنده , , Brian Scott، نويسنده , , Michael Webb، نويسنده , , Sandra R. Chaplan، نويسنده , , J. Guy Breitenbucher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2109
To page
2113
Abstract
Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats.
Keywords
pain , endocannabinoid , Fatty acid amide hydrolase , FAAH
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799308
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