Title of article
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium
Author/Authors
Jeong Hoon Yoon، نويسنده , , Hyo Jin Lim، نويسنده , , Hwa-Jin Lee، نويسنده , , Hee-Doo Kim، نويسنده , , Raok Jeon، نويسنده , , Jae-Ha Ryu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2179
To page
2182
Abstract
Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC50 values: 0.47, 11.2, 136.5 μM, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-κB through the inhibition of LPS-induced I-κB-α degradation in microglia.
Keywords
Nitric oxide synthase , Cyclooxygenase , Xanthium strumarium , sesquiterpene , nuclear factor ?B
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799320
Link To Document