Title of article
Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors
Author/Authors
Hui Huang، نويسنده , , Daniel A. Hutta، نويسنده , , Huaping Hu، نويسنده , , Renee L. DesJarlais، نويسنده , , Paul B. Sigler and Carsten Schubert، نويسنده , , Ioanna P. Petrounia، نويسنده , , Margery A. Chaikin، نويسنده , , Carl L. Manthey، نويسنده , , Mark R. Player، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
2355
To page
2361
Abstract
A series of pyrimidinopyridones has been designed, synthesized and shown to be potent and selective inhibitors of the FMS tyrosine kinase. Introduction of an amide substituent at the 6-position of the pyridone core resulted in a significant potency increase. Compound 24 effectively inhibited in vivo LPS-induced TNF in mice greater than 80%.
Keywords
FMS , CSF-1 , cFMS , M-CSF , macrophage , Pyrimidinopyridone , Colony-stimulating factor-1 receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799359
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