Title of article
Inhibitors of anthrax lethal factor based upon N-oleoyldopamine
Author/Authors
Brandon D. Gaddis، نويسنده , , Charles M. Rubert Pérez، نويسنده , , Jean Chmielewski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2467
To page
2470
Abstract
The structural features of an anthrax lethal factor inhibitor, N-oleoyldopamine (OLDA, 1) have been probed. The oleic acid moiety is critical, but, more interestingly, the presence of the double bond and its geometry were found to play an essential role. One compound, 5, was found to be an uncompetitive inhibitor of lethal factor (LF) with a Ki value of 2.2 μM and a cell-based IC50 value of 4.3 μM.
Keywords
Anthrax , Lethal factor , Uncompetitive inhibition , Anti-toxin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799384
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