Title of article
Synthesis and PKCθ inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles
Author/Authors
Diane H. Boschelli، نويسنده , , Biqi Wu، نويسنده , , Ana Carolina Barrios Sosa، نويسنده , , Joan Chen، نويسنده , , Magda Asselin، نويسنده , , Derek C. Cole، نويسنده , , Julie Lee، نويسنده , , Xiaoke Yang، نويسنده , , Divya Chaudhary، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2850
To page
2853
Abstract
The thieno[2,3-b]pyridine-5-carbonitrile with a 5-indolylamine at C-4 and a phenyl group at C-2 had a moderate activity against PKCθ. Optimization of the groups at C-4 and C-2 led to analog 29, which has an IC50 value of 7.5 nM for the inhibition of PKCθ.
Keywords
3-b]pyridine-5-carbonitrile , PKC?
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799459
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