• Title of article

    Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists

  • Author/Authors

    Gavin A. Whitlock، نويسنده , , Kelly Conlon، نويسنده , , Gordon McMurray، نويسنده , , Lee R. Roberts، نويسنده , , Alan Stobie، نويسنده , , Richard J. Thurlow، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    5
  • From page
    2930
  • To page
    2934
  • Abstract
    Novel 2-imidazoles have been identified as potent partial agonists of the α1A adrenergic receptor, with good selectivity over the α1B, α1D and α2A receptor sub-types. Sulfonamide 23 possessed attractive drug-like properties with respect to physicochemical and ADME properties and wide ligand selectivity.
  • Keywords
    Drug-like properties , ?1A Adrenoceptor , Partial agonist , 2-Imidazole , Selectivity
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2008
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    799475

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799475