Title of article
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase
Author/Authors
Suresh K. Tipparaju، نويسنده , , Sipak Joyasawal، نويسنده , , Sara Forrester، نويسنده , , Debbie C. Mulhearn، نويسنده , , Scott Pegan، نويسنده , , Michael E. Johnson، نويسنده , , Andrew D. Mesecar، نويسنده , , Alan P. Kozikowski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3565
To page
3569
Abstract
Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.
Keywords
Anthrax
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799600
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