Title of article
C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I
Author/Authors
Yifan Wang، نويسنده , , Magdeline Tao Tao Ng، نويسنده , , Tianyan Zhou، نويسنده , , Xinming Li، نويسنده , , Choon Hong Tan، نويسنده , , Tianhu Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
3597
To page
3602
Abstract
Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes.
Keywords
Circular oligonucleotide , Human topoisomerase I , Enzyme inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799609
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