Title of article
Design of a fluorescence polarization assay platform for the study of human Hsp70
Author/Authors
Yanlong Kang، نويسنده , , Tony Taldone، نويسنده , , Cristina C. Clement، نويسنده , , Sheara W. Fewell، نويسنده , , Julia Aguirre، نويسنده , , Jeffrey L. Brodsky، نويسنده , , Gabriela Chiosis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
3749
To page
3751
Abstract
The 70 kDa heat shock proteins (Hsp70) are molecular chaperones that assist in folding of newly synthesized polypeptides, refolding or denaturation of misfolded proteins, and translocation of proteins across biological membranes. In addition, Hsp70 play regulatory roles in signal transduction, cell cycle, and apoptosis. Here, we present a novel assay platform based on fluorescence polarization that is suitable for investigating the yet elusive molecular mechanics of human Hsp70 allosteric regulation.
Keywords
Hsp70 , heat shock protein 70
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799648
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