Title of article
Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency
Author/Authors
Mavurapu Satyanarayana، نويسنده , , Suzanne G. Rzuczek، نويسنده , , Edmond J. LaVoie، نويسنده , , Daniel S. Pilch، نويسنده , , Y. Angela Liu، نويسنده , , Leroy F. Liu، نويسنده , , Joseph E. Rice، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
3802
To page
3804
Abstract
The synthesis of a 24-membered macrocyclic hexaoxazole via ring-closing metathesis is described. The target compound selectively stabilizes G-quadruplex DNA with no detectable stabilization of duplex DNA. An MTT cytotoxicity assay indicated that this unsaturated macrocyclic hexaoxazole exhibits significant cytotoxicity toward P388, RPMI 8402, and KB3-1 cell lines with IC50 values of 45, 25, and 38 nM, respectively.
Keywords
Synthesis , Macrocycle , G-quadruplex stabilizer , ring-closing metathesis , Selective , Cytotoxic , Hexaoxazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799661
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