Title of article
Synthesis of 5″-branched derivatives of cyclic ADP-carbocyclic-ribose, a potent Ca2+-mobilizing agent: The first antagonists modified at the N1-ribose moiety
Author/Authors
Natsumi Sakaguchi، نويسنده , , Takashi Kudoh، نويسنده , , Takayoshi Tsuzuki، نويسنده , , Takashi Murayama، نويسنده , , Takashi Sakurai، نويسنده , , Akira Matsuda and Fuyuhiko Inagaki، نويسنده , , Mitsuhiro Arisawa، نويسنده , , Satoshi Shuto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3814
To page
3818
Abstract
The 5″-branched cyclic ADP-carbocyclic-ribose derivatives were designed and synthesized. These target compounds were identified as the first antagonists of cADPR without a substituent at the adenine 8-position, and were shown to be stable due to the N1-carbocyclic-ribosyl structure.
Keywords
Ca2+-mobilization , cADPR , nucleotide , second messenger
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799664
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