Title of article
Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands
Author/Authors
Saurin Raval، نويسنده , , Preeti Raval، نويسنده , , Debdutta Bandyopadhyay، نويسنده , , Krunal Soni، نويسنده , , Digambar Yevale، نويسنده , , Digvijay Jogiya، نويسنده , , Honey Modi، نويسنده , , Amit Joharapurkar، نويسنده , , Neha Gandhi، نويسنده , , Mukul R. Jain، نويسنده , , Pankaj R. Patel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
3919
To page
3924
Abstract
Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy-cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.
Keywords
Squaric acid , Thyroid receptor assay , 3-Hydroxy-cyclobut-3-ene-1 , 2-dione , TR-? Selective , Thyroid hormone receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799683
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