Title of article
Urotensin-II receptor antagonists: Synthesis and SAR of N-cyclic azaalkyl benzamides
Author/Authors
Jian Jin، نويسنده , , Ming An، نويسنده , , Anthony Sapienza، نويسنده , , Nambi Aiyar، نويسنده , , Diane Naselsky، نويسنده , , Henry M. Sarau، نويسنده , , James J. Foley، نويسنده , , Kevin L. Salyers، نويسنده , , Steven D. Knight، نويسنده , , Richard M. Keenan، نويسنده , , Ralph A. Rivero، نويسنده , , Dashyant Dhanak، نويسنده , , Stephen A. Douglas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3950
To page
3954
Abstract
SAR exploration of the central diamine, benzyl, and terminal aminoalkoxy regions of the N-cyclic azaalkyl benzamide series led to the identification of very potent human urotensin-II receptor antagonists such as 1a with a Ki of 4 nM. The synthesis and structure–activity relationships (SAR) of N-cyclic azaalkyl benzamides are described.
Keywords
N-cyclic azaalkyl benzamides , Urotensin-II receptor antagonist , UT antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799690
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