Title of article
Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia
Author/Authors
Guo Hua Jin، نويسنده , , Sang Keun Ha، نويسنده , , Hye Min Park، نويسنده , , Bomi Kang، نويسنده , , Sun Yeou Kim، نويسنده , , Hee-Do Kim، نويسنده , , Jae-Ha Ryu، نويسنده , , Raok Jeon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
4092
To page
4094
Abstract
A series of azaisoflavones were synthesized and their biological activities were evaluated for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in BV-2 microglia cell lines. Among these compounds, compound 8d was the most potent with IC50 7.83 μM for inhibition of NO production. Also, compound 8d inhibited expression of iNOS in LPS-induced BV2 cells. This result suggests that compound 8d inhibited the production of NO by suppressing the expression of iNOS.
Keywords
nitric oxide , INOS , Azaisoflavone
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799723
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