Title of article
Molecular recognition of a DNA:RNA hybrid: Sub-nanomolar binding by a neomycin–methidium conjugate
Author/Authors
Nicholas N. Shaw، نويسنده , , Hongjuan Xi، نويسنده , , Dev P. Arya، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4142
To page
4145
Abstract
A novel neomycin–methidium conjugate was synthesized. The covalent linkage of the aminoglycoside to an intercalator, a derivative of ethidium bromide, results in a new conjugate capable of selective recognition of the DNA:RNA hybrid duplex. Spectroscopic methods: UV, CD, fluorescence, and calorimetric techniques: DSC and ITC were used to characterize the sub-nanomolar binding displayed by the conjugate for the DNA:RNA hybrid duplex, poly(dA):poly(rU).
Keywords
aminosugar , ethidium bromide , Intercalator , Aminoglycoside , Neomycin , RNA , DNA:RNA hybrid , telomerase , DNA
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799735
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