Title of article
The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity
Author/Authors
Tony Siu، نويسنده , , Yiwei Li، نويسنده , , Johnny Nagasawa، نويسنده , , Jun Liang، نويسنده , , Lida Tehrani، نويسنده , , Peter Chua، نويسنده , , Raymond E. Jones، نويسنده , , Deborah Defeo-Jones، نويسنده , , Stanley F. Barnett، نويسنده , , Ronald G. Robinson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4191
To page
4194
Abstract
This letter details the attenuation of hERG in a class of Akt inhibitors through heteroatom insertions into aromatic rings. The development of a cell-active dual Akt 1 and 2 inhibitors devoid of hERG activity is discussed using structure–activity relationships.
Keywords
HERG , Allosteric , Akt , kinase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799746
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