Title of article
Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers
Author/Authors
Damien Barbaras، نويسنده , , Marcel Kaiser، نويسنده , , Reto Brun، نويسنده , , Karl Gademann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
4413
To page
4415
Abstract
The quaternary β-carbolinium alkaloid nostocarboline from the cyanobacterium Nostoc 78-12A and 10 bis-cationic dimeric derivatives were evaluated against four protozoan parasites and low micromolar values against Trypanosoma brucei, submicromolar values against Leishmania donovani and low nanomolar values against Plasmodium falciparum K1 were determined. Selectivity against rat myoblasts (L6 cells) was found to be up to >2500-fold.
Keywords
Antiprotozoal , malaria , natural products , pentamidine , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799796
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