Title of article
A novel peptide from α5 helix of Asterina pectinifera cyclin B conjugated to HIV-Tat49–57 with cytotoxic and apoptotic effects against human cancer cells
Author/Authors
Huiping Lou، نويسنده , , Yanfeng Gao، نويسنده , , Mingxia Zhai، نويسنده , , Yuanming Qi، نويسنده , , Lixiang Chen، نويسنده , , Hong Lv، نويسنده , , Jibing Yu، نويسنده , , Yongxin Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4633
To page
4637
Abstract
A series of novel peptides from various motifs of Asterina pectinifera cyclin B and their derivatives conjugated to HIV-Tat49–57 were designed and synthesized. Their bioactivities on two human cancer cell lines were determined. Among them, Tat-a5 (KAQIRAMECNILGRKKRRQRRR) exhibited significant cytotoxic effects on cancer cell lines EC-9706 and HCT-116. Tat-a5 could arrest cancer cells at G2/M phase and make them apoptotic. Our results suggested that Tat-a5 could be a novel leading peptide with anticancer activity.
Keywords
peptide , Asterina pectinifera , Anticancer , Cyclin B , Apoptosis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799847
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