Title of article
Synthesis and biological evaluation of novel 3′-N-tert-butylsulfonyl analogues of docetaxel
Author/Authors
Bowen Ke، نويسنده , , Yong Qin، نويسنده , , Fengyan Zhao، نويسنده , , Yi Qu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
4783
To page
4785
Abstract
Novel 3′-N-tert-butylsulfonyl analogues 10a–c of docetaxel were synthesized and their biological evaluation in cytotoxicity in vitro against several human tumor cell lines were presented. The biologically tested results showed that N-oxide pyridyl substituted10b–c had potent cytotoxicities against human tumor cell lines Eca-109, SKOV3, SMMC-7721, HCT-8, PC3, MCF-7, HeLa and KB.
Keywords
Docetaxel analogue , synthesis , Antitumor activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799886
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