Title of article
Synthesis of potent water-soluble tissue transglutaminase inhibitors
Author/Authors
Martin Griffin، نويسنده , , Alexandre Mongeot، نويسنده , , Russell Collighan، نويسنده , , Robert E. Saint، نويسنده , , Richard A. Jones، نويسنده , , Ian G.C. Coutts، نويسنده , , Daniel L. Rathbone، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
5559
To page
5562
Abstract
Dipeptide-based sulfonium peptidylmethylketones derived from 6-diazo-5-oxo-l-norleucine (DON) have been investigated as potential water-soluble inhibitors of extracellular transglutaminase. The lead compounds were prepared in four steps and exhibited potent activity against tissue transglutaminase.
Keywords
transglutaminase , inhibitors , dipeptide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800057
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