Title of article
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators
Author/Authors
Colleen M. Niswender، نويسنده , , Evan P. Lebois، نويسنده , , Qingwei Luo، نويسنده , , Kwangho Kim، نويسنده , , Hubert Muchalski، نويسنده , , Huiyong Yin، نويسنده , , P. Jeffrey Conn، نويسنده , , Craig W. Lindsley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
5626
To page
5630
Abstract
This letter describes the synthesis and SAR, developed through an iterative analogue library approach, of an mGluR4 positive allosteric modulator lead based on a pyrazolo[3,4-d]pyrimidine scaffold. Despite tremendous therapeutic potential, Compound 7, VU0080421, and related congeners represent only a handful of mGluR4 positive allosteric modulators ever described.
Keywords
Positive allosteric modulator , Parkinson’s disease , GPCR , PAM , mGluR4
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800073
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