• Title of article

    Design at the atomic level: Generation of novel hybrid biaryloxazolidinones as promising new antibiotics

  • Author/Authors

    Jiacheng Zhou، نويسنده , , Ashoke Bhattacharjee، نويسنده , , Shili Chen، نويسنده , , Yi Chen، نويسنده , , Erin Duffy، نويسنده , , Jay Farmer، نويسنده , , Joel Goldberg، نويسنده , , Roger Hanselmann، نويسنده , , Joseph A. Ippolito، نويسنده , , Rongliang Lou، نويسنده , , Alia Orbin، نويسنده , , Ayomi Oyelere، نويسنده , , Joe Salvino، نويسنده , , Dane Springer، نويسنده , , Jennifer Tran، نويسنده , , Chengjie Zhao and Deping Wang، نويسنده , , Yusheng Wu، نويسنده , , Graham Johnson، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    5
  • From page
    6179
  • To page
    6183
  • Abstract
    From the X-ray crystal structures of linezolid and the non-selective antibiotic sparsomycin, we have derived a new family of hybrid oxazolidinones. From this initial compound set we have developed a new biaryloxazolidinone scaffold that shows both potent antimicrobial activity as well as selective inhibition of ribosomal translation. The synthesis of these compounds is outlined.
  • Keywords
    Linezolid , Sparsomycin , Gram-negative bacteria , X-ray crystal structure , Oral antibiotics , ribosome , Hybrid antibiotics , Oxazolidinone , structure-based drug design , Biaryloxazolidinone
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2008
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    800197

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=800197