Title of article
The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor
Author/Authors
Susan M. Westaway، نويسنده , , Samantha L. Brown، نويسنده , , Elizabeth Conway، نويسنده , , Tom D. Heightman، نويسنده , , Christopher N. Johnson، نويسنده , , Kate Lapsley، نويسنده , , Gregor J. Macdonald، نويسنده , , David T. MacPherson، نويسنده , , Darren J. Mitchell، نويسنده , , James W. Myatt، نويسنده , , Jon T. Seal، نويسنده , , Steven J. Stanway، نويسنده , , Geoffrey Stemp، نويسنده , , Mervyn Thompson، نويسنده , , Paolo Celestini، نويسنده , , Andrea Colombo، نويسنده , , Alessandra Consonni، نويسنده , , Stefania Gagliardi، نويسنده , , Mauro Riccaboni، نويسنده , , Silvano Ronzoni، نويسنده , , et al.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
6429
To page
6436
Abstract
Optimisation of urea (5), identified from high throughput screening and subsequent array chemistry, has resulted in the identification of pyridine carboxamide (33) which is a potent motilin receptor agonist possessing favourable physicochemical and ADME profiles. Compound (33) has demonstrated prokinetic-like activity both in vitro and in vivo in the rabbit and therefore represents a promising novel small molecule motilin receptor agonist for further evaluation as a gastroprokinetic agent.
Keywords
Motilin , Motilin receptor agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800251
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