Title of article
Synthesis and structure–activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists
Author/Authors
Mingde Xia، نويسنده , , Cuifen Hou، نويسنده , , Duane DeMong، نويسنده , , Scott Pollack، نويسنده , , Meng Pan، نويسنده , , Monica Singer، نويسنده , , Michele Matheis، نويسنده , , L. William Murray، نويسنده , , Druie Cavender، نويسنده , , Michael Wachter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
6468
To page
6470
Abstract
The synthesis and structure–activity relationship of a series of 7-azaindole piperidine derivatives are described. SAR studies led to the discovery of the potent CCR2 antagonists displaying IC50 values in the nanomolar range. The representative compound 15 showed reasonable P450 and pharmacokinetics profile.
Keywords
CCR2 antagonist , chemokines , MCP-1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800260
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