Title of article
3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors
Author/Authors
Jeffrey W. Corbett، نويسنده , , Senliang Pan، نويسنده , , Jay A. Markwalder، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , Sena Garber، نويسنده , , James D. Rodgers III، نويسنده , , Susan K. Erickson-Viitanen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
211
To page
214
Abstract
A series of unique 3,3a-dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones and a 2a,5-dihydro-2H-thieno[4,3,2-de]quinazoline-4(3H)-thione were found to be HIV-1 non-nucleoside reverse transcriptase inhibitors. One of these compounds, as the racemate, possessed an IC90=4.6 nM against wild-type virus in a whole cell antiviral assay and had an IC90=76 and 897 nM against the clinically significant K103N and K103N/L100I mutant viruses, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800311
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