Title of article
Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents
Author/Authors
Zhili Li، نويسنده , , Michael W. Fennie، نويسنده , , Bruce Ganem، نويسنده , , Matthew T. Hancock، نويسنده , , Muris Koba lija، نويسنده , , Donna Rattendi، نويسنده , , Cyrus J. Bacchi، نويسنده , , Mary C. OʹSullivan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
251
To page
254
Abstract
Several N-(3-phenylpropyl)-substituted spermidine and spermine derivatives were prepared and found to be potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase (seven compounds with Ki values <5 μM are described). The most effective inhibitor studied was compound 12 with a Ki value of 0.151 μM. Six of the compounds described are also effective trypanocides with IC50 values <1 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800321
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