Title of article
Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of hIV-1 non-nucleoside reverse transcriptase
Author/Authors
Jeffrey W. Corbett، نويسنده , , Kristen J. Kresge، نويسنده , , Senliang Pan، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , James D. Rodgers III، نويسنده , , Susan K. Erickson-Viitanen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
309
To page
312
Abstract
3-Alkoxymethyl- and 3-aryloxymethyl-2-pyridinones were synthesized and evaluated for activity as non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1. It was found that several compounds were potent inhibitors of HIV-1 with the most potent compound 24 exhibiting an IC90=32 nM. Compound 24 also possessed a potent resistance profile as demonstrated by submicromolar IC90s against several clinically meaningful mutant virus strains.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800334
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