Title of article
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective α7 nicotinic receptor partial agonist
Author/Authors
John E. Macor، نويسنده , , David Gurley، نويسنده , , Thomas Lanthorn، نويسنده , , James Loch، نويسنده , , Robert A. Mack، نويسنده , , George Mullen، نويسنده , , Oahn Tran، نويسنده , , Nicole Wright، نويسنده , , John C. Gordon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
319
To page
321
Abstract
The 5-HT3 receptor antagonist tropisetron (ICS 205-930) was found to be a potent and selective partial agonist at α7 nicotinic receptors. Two other 5-HT3 receptor antagonists, ondansetron and LY-278,584, were found to lack high affinity at the α7 nicotinic receptor. Quinuclidine analogues (1 and 2) of tropisetron were also found to be potent and selective partial agonists at α7 nicotinic receptors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800336
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