Title of article
Human β3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties
Author/Authors
Linda L. Brockunier، نويسنده , , Mari R. Candelore، نويسنده , , Margaret A. Cascieri، نويسنده , , Yong Liu، نويسنده , , Laurie Tota، نويسنده , , Matthew J. Wyvratt Jr.، نويسنده , , Michael H. Fisher، نويسنده , , Ann E. Weber، نويسنده , , Emma R. Parmee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
379
To page
382
Abstract
Pyridineethanolamine derivatives containing cyanoguanidine or nitroethylenediamine moieties were examined as human β3 adrenergic receptor (AR) agonists. Notably, indoline derivatives 6a and 11 were potent β3 AR agonists (β3 EC50=13 and 19 nM, respectively), which showed good selectivity over binding to and minimal activation of the β1 and β2 ARs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800351
Link To Document