Title of article
FR131535, a novel water-soluble echinocandin-like lipopeptide: synthesis and biological properties
Author/Authors
Akihiko Fujie، نويسنده , , Toshiro Iwamoto، نويسنده , , Bunji Sato، نويسنده , , Hideyuki Muramatsu، نويسنده , , Chiyoshi Kasahara، نويسنده , , Takahisa Furuta، نويسنده , , Yasuhiro Hori، نويسنده , , Motohiro Hino، نويسنده , , Seiji Hashimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
399
To page
402
Abstract
The synthesis and biological properties of a novel water-soluble echinocandin-like lipopeptide, FR131535, are described. This compound displayed potent in vitro and in vivo antifungal activities. The hemolytic activity of FR901379 was reduced by replacing the acyl side chain. This compound showed good water-solubility, comparable to the natural product FR901379.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800356
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