Title of article
Anti-Helicobacter pylori agents endowed with H2-antagonist properties
Author/Authors
Giovanni Sorba، نويسنده , , Massimo Bertinaria، نويسنده , , Antonella Di Stilo، نويسنده , , Alberto Gasco، نويسنده , , Maria M. Scaltrito، نويسنده , , Maria I. Brenciaglia، نويسنده , , Francesco Dubini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
403
To page
406
Abstract
New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800357
Link To Document