Title of article
Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor Efavirenz
Author/Authors
Jay A. Markwalder، نويسنده , , David D. Christ، نويسنده , , Abdul Mutlib، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , Steven P. Seitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
619
To page
622
Abstract
Studies on the biotransformation of the clinically important non-nucleoside reverse transcriptase inhibitor efavirenz have shown that oxidation and secondary conjugation are important components of the processing of this molecule in vivo. We have synthesized metabolites of efavirenz to confirm their structure and to evaluate their activity as antivirals.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800408
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