Vaccination against follistatin and the effect on ovulation rate in estrus-induced gilts

Christensen, C. R., Redmond, M. J. and Laarveld, B. 2003. Vaccination against follistatin and the effect on ovulation rate in estrus-induced gilts. Can. J. Anim. Sci. 83: 487-492. Primiparous sows were vaccinated against follistatin to determine the effect on ovulation rate following typical commercial estrus induction and synchronizations Seventy-five gilts received four vaccinations against a recombinant porcine follistatin (FS) or a sham vaccine (CTL). At 85 kg, gilts were induced into estrus with a combination of PG600 and hCG and synchronized using PGF(2alpha). At the second estrus, antibody titers ranged from 0 to 1:6400 in the FS-vaccinated treatment group and no FS antibodies were detected in the CTL group. Late in the second subsequent luteal phase the reproductive tracts of the gilts that had displayed two estruses were collected. There was no significant difference in the number of corpora lutea (FS = 13.2 +- 0.5, CTL = 14.5 +- 0.7) or corpora albicantia (FS = 12.1 +- 1.9, CTL = 12.3 +- 2.0) between treatments. Follistatin-vaccinated gilts displayed an increased number of luteal structures which resembled corpora hemorrhagica (P = 0.04). This study shows that vaccination of gilts against FS concurrent with estrus induction and synchronization affected ovarian morphology, although an effect on ovulation rate was not apparent.