Title of article
Influence of aging on thromboxane A2 and prostacyclin levels in rat hippocampal brain slices
Author/Authors
F. Marmol، نويسنده , , P. Puig-Parellada، نويسنده , , J. Sanchez، نويسنده , , R. Trullas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
3
From page
695
To page
697
Abstract
We have investigated the influence of age (3, 18, 24 months) on Thromboxane A2 (TXA2) and Prostacyclin (PGI2) levels in hippocampal slices from F344/NHSD rats. A significant increase in TXA2 and PGI2 levels was observed in 18 and 24 months old compared to 3 months old animals. A significant reduction in the ratio TXA2/PGI2 produced by a higher increase in PGI2 was observed in 24 month old animals. The reduction in the TXA2/PGI2 ratio has been related to vasodilatory and antiaggregating effects that may contribute to protect the brain against neuronal damage.
Keywords
aging , prostacyclin , Hippocampus , thromboxane
Journal title
Neurobiology of Aging
Serial Year
1999
Journal title
Neurobiology of Aging
Record number
819880
Link To Document