Title of article
A TAP2 genotype associated with Alzheimerʹs disease in APOE4 carriers
Author/Authors
Mar?a J. Bullido، نويسنده , , Ana Mart?nez-Garc?a، نويسنده , , Mar?a J. Artiga، نويسنده , , Jes?s Aldudo، نويسنده , , Isabel Sastre، نويسنده , , Pedro Gil، نويسنده , , Francisco Coria، نويسنده , , David G. Munoz، نويسنده , , Vladimir Hachinski، نويسنده , , Ana Frank، نويسنده , , Fernando Valdivieso، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
519
To page
523
Abstract
Sporadic Alzheimerʹs disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case–control samples, especially in carriers of the APOE4 allele. These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD.
Keywords
Alzheimer’s Disease , Genetic risk factor , TAP , APOE , interaction
Journal title
Neurobiology of Aging
Serial Year
2007
Journal title
Neurobiology of Aging
Record number
820960
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