The muscle fatigue fiber model Original Research Article

The aim of this study was to integrate the effect of muscle fatigue into the skeletal muscle fiber model, which was previously developed in our laboratory and was based on the modified Huxley equation with the calcium activation taken into account. The cellular mechanisms such as (i) the attachment of myosin heads to the actin binding sites, (ii) the actin filament activation, (iii) the sensitivity of myofilaments to calcium ions and (iv) the calcium handling; which influence the force generated by the muscle fiber and are affected during fatigue, became the base stone for the development of the muscle fatigue fiber model.