Title of article
Unique Variant Complex Chromosome Translocation in Myeloid Leukemia: Report of a Case and Literature Review
Author/Authors
Movafagh، Abolfazl نويسنده Medical Genetics Department, Shaheed Beheshti University of Medical Sciences , , Hashemi، Mehrdad نويسنده , , Ghadiani، Mojtaba نويسنده Department of Internal Medicine/Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Mirfakhraei، Reza نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Darvish، Hossein نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Zare Abdollahi، Davood نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Ghaedi، Hamid نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Safari، Shamsi نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , HaghNejad، Leyla نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Mosammami، Sara نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Safavi Naeini، Niloofar نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Miri، Ramin نويسنده , , Rezaei-Tavirani، Mostafa نويسنده ,
Issue Information
فصلنامه با شماره پیاپی 10 سال 2012
Pages
4
From page
85
To page
88
Abstract
Background: According to the literature, there are a number of chronic and acute
myeloid leukemias with unique, complex chromosome translocations. This study
aims to conduct a brief review of the incidence of complex chromosome translocations
in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome
translocations.
Methods: We conducted a web-based search for all peer review articles published
on the subject of complex chromosome tranlsocations in chronic and acute myeloid
leukemia in MEDLINE, PubMed and Mitelman (http://cgapanci.nih.gov/
chromosomes/Mitelman) databases in addition to other pertinent web references. In
addition, we performed conventional cytogenetic studies of 24- to 72-h cultures on bone
marrow/peripheral blood cells obtained from the current case. Cells were finally
treated by the giemsa-trypsin-giemsa banding technique.
Results: The result of this case revealed an abnormal karyotype that had a novel
complex translocation which involved chromosomes 2, 5, 9, and 22. We performed
karyotyping after the initiation of chemotherapy. Karyotyping results showed a complex
karyotype 46,XX,t(9;22;2;5).
Conclusion: This study discusses a case of chronic myeloid leukemia with complex
chromosome translocations and may provide novel information regarding these
translocations in leukemias.
Journal title
Middle East Journal of Cancer (MEJC)
Serial Year
2012
Journal title
Middle East Journal of Cancer (MEJC)
Record number
889660
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