(beta)-Carotene-vitamin A equivalence in Chinese adults assessed by an isotope dilution technique

The present study was carried out to determine the conversion factor of synthetic 2H-labelled (beta)-carotene (6 mg) in oil on the first day of the experiment, and a reference dose of [2H8]retinyl acetate (3 mg) in oil was given on the fourth day. Serum samples were collected at 0, 3, 5, 7, 9, 11, and 13 h on the first and the fourth days of the study, daily for 10 d, and then weekly from days 14 to 56. (beta)-carotene to vitamin A conversion factors of >29·0:1 on a molar basis and were termed ‘poor converters’. In the eleven normal converters (seven males and four females), the calculated conversion factors of (beta)carotene to retinol ranged from 2·0:1 to 12·2:1 with an average of 4·8 (sd 2·8):1 on a molar basis, and from 3·8:1 to 22·8:1 with an average of 9·1 (sd 5·3):1 on a weight basis. The 52 d post-intestinal absorption conversion was estimated to be about 30 % of the total converted retinol.