Title of article
Thermal glycosylations: Reactions of β-cellobiosyl fluoride heptaacetate with tigogenin and its trimethylsilyl ether
Author/Authors
Kathleen D Goggin، نويسنده , , Jack F Lambert، نويسنده , , Stanley W Walinsky، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 1997
Pages
5
From page
347
To page
351
Abstract
Thermal reaction of β-cellobiosyl fluoride heptaacetate with ticogenin in toluene or o-xylene at 112–142 °C gave ticogenyl β-cellobioside heptaacetate in 69–75% yields with good stereoselectivity. The procedure avoids the use of Lewis acid or traditional glycosidation promotors. The deacetylated product is a hypocholesterolemic and anti-atherosclerosis agent.
Keywords
Tigogenyl ?-cellobioside , Me3Si-O-tigogenin , Cholesterol-lowering agent , Stereoselective thermal glycosylations , Tigogenin , ?-Cellobiosyl fluoride heptaacetate , Tigogenyl ?-cellobioside heptaacetate
Journal title
Carbohydrate Research
Serial Year
1997
Journal title
Carbohydrate Research
Record number
961896
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