Title of article
Total synthesis of the natural antigen involved in the hyperacute rejection response to xenotransplants Original Research Article
Author/Authors
Christian Gege، نويسنده , , Willy Kinzy، نويسنده , , Richard R. Schmidt، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2000
Pages
8
From page
459
To page
466
Abstract
The major glycosphingolipid in pig vascular endothelium is the ceramide pentasaccharide Galα(1→3)Galβ(1→4)GlcNAcβ(1→3)Galβ(1→4)Glcβ(1→0)Cer (1), which binds specifically to human anti-Gal antibody and is involved in the hyperacute rejection response in xenotransplantation from pig to man. The synthesis of 1 and its methyl glycoside 2 is described.
Keywords
O-Glycosylation , Synthesis , ?-Galactosyl epitopes , Xenotransplantation , Glycosphingolipid , Ceramide
Journal title
Carbohydrate Research
Serial Year
2000
Journal title
Carbohydrate Research
Record number
962759
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